You should be able to write an AppleScript (via Script Editor, AppleScript Editor, whatever).

Open Script Editor– type:

tell application “Terminal”
do script “mono /$PATH_TO_KEEPASS.exe”
end tell

(This assumes you have mono in your preference file– if you have to move to the mono directory to run it or type out the full path to mono every time to run Keepass, you will also have to do the same here).

Press “compile.” Save it in the “Applications” folder. Make sure the file format is set to “Application” and leave Startup Screen unchecked.

Now open your Applications folder in Finder and click and drag to the dock. When you click on this, it should open a terminal window and run Mono/Keepass automatically without need to manually type in mono Keepass.exe or whatever.

This is very true! Mac users might also be able to use Wine to run Keepass v2, but I only like using Wine/Mono when I have to (otherwise native is the way to go).

That said, if .kdbx support is a critical feature for existing Keepass users, then either of the two pieces of software above installed in conjunction with Keepass v2 is the way to go.

-Colin

…I discovered this out of necessity when my wife bought macbook and we needed to access our already very large pw safe.

cheers!